Bryan Strange, Guillermo Velasco
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may
15may19:0020:30Pint of Science 2024CA REVOLTA
Event Details
More Info: https://pintofscience.es/events/valencia
Event Details
More Info: https://pintofscience.es/events/valencia
Time
(Wednesday) 19:00 - 20:30(GMT+02:00)
Location
CA REVOLTA
C/ Santa Teresa, 10
16may12:0013:00SEMINAR: Marina Fuertes Agudo / Daniel Tena González
Event Details
12:00 – 12:30 Marina Fuertes Agudo 3D cell cultures for modeling liver pathologies Abstract 12:30 – 13:00 Daniel Tena González Inhibition of NLRP3 inflammasome in models of retinal degenerations
Event Details
12:00 – 12:30 Marina Fuertes Agudo
3D cell cultures for modeling liver pathologies
Abstract
12:30 – 13:00 Daniel Tena González
Inhibition of NLRP3 inflammasome in models of retinal degenerations
Abstract
Time
(Thursday) 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Event Details
Title: New advanced anti-tumor therapies based on hybrid mesoporous nanodevices Autor: Elena Lucena Sánchez Abstract: The present PhD thesis entitled “New advanced anti-tumor therapies based on hybrid mesoporous nanodevices” focuses
Event Details
Title: New advanced anti-tumor therapies based on hybrid mesoporous nanodevices
Autor: Elena Lucena Sánchez
Abstract: The present PhD thesis entitled “New advanced anti-tumor therapies based on hybrid mesoporous nanodevices” focuses on the design, synthesis, characterization, and evaluation of new hybrid organic-inorganic nanodevices. We have developed mesoporous silica nanoparticles (MSNs) and Janus platinum-MSN and gold-MSN nanoparticles for tumor treatment.
The first chapter is a general introduction that includes an overview of the context related to the research developed in this thesis. In particular, the concept of nanotechnology and nanomedicine are presented, as well as basic information about mesoporous silica nanoparticles, janus nanoparticles, and their interactions with biological systems. Finally, cancer disease characteristics, actual treatments, and the application of nanomaterials as therapy are described.
Next, in the second chapter, the general objectives of this Ph.D. thesis and the specific objectives addressed in the following experimental chapters are presented.
The third and fourth chapters describe two nanotechnology-based therapeutic strategies based on the development of nanomotors to improve cancer therapy. Specifically, the first experimental chapter presents a self-moving nanodevice for controlled drug release in response to intracellular glutathione (GSH). It is based on Janus gold-mesoporous silica nanoparticles functionalized with the enzyme catalase in the gold face, loaded with doxorubicin and capped with disulfide-linked oligo(ethylene glycol) (S-S-PEG) chains on the silica face. Once synthesized and characterized, the nanosystem motion capability through hydrogen peroxide (fuel) conversion into oxygen by catalase was confirmed. The proper gating mechanism of the nanodevice was tested in the presence of GSH, thus corroborating that cargo release only occurs in the presence of the tripeptide. The cellular uptake and doxorubicin release capacity have been demonstrated in the human cervix cell line Hela, being increased in the presence of fuel.
Encouraged by the above results, chapter four describes a similar nanomotor design for antitumor therapy. In this case, the nanoparticle developed is composed of a Janus platinum-mesoporous silica nanoparticle, loaded with doxorubicin, and capped with S-S-PEG. As well as in the previous work, the catalytic decomposition of low concentrations of hydrogen peroxide, in this case by platinum, induced self-propulsion of the nanoparticles. The stimuli-responsive
cargo release kinetic profile was obtained and its application was confirmed in a monolayer THP-1 cell culture and in a microchip device mimicking capillary vessels.
Chapters five and six focus on a new therapeutic strategy, empowering the immune system action on tumors to reach tumor cell death. In the first of these experimental chapters, JQ-1 and transforming growth factor-beta (TGF-β) siRNA-loaded nanoparticles were used as efficient tumor immunotherapy. This nanodevice is based on MSNs loaded with JQ-1 drug, functionalized with polyethyleneimine (PEI) and a siRNA targeting TGF-β was binding through electrostatic interaction. The endosomal escape and efficient cytosolic delivery of siRNA by PEI was accomplished by using these nanoparticles, along with the programmed death-ligand 1 (PD-L1) downregulation and TGF-β silencing. Lastly, its application was confirmed by triggering a specific immunogenic removal of tumor cells in melanoma A375 cells pre-treated with nanoparticles.
In chapter six, the development of a new communication-based immunotherapeutic approach is reported. In this case, we employ Janus gold-MSN functionalized with a peptide called pHLIP onto silica face and anti-PD-1 antibody bound to gold face (J-pHLIP-PD1). Tumor cell membrane is decorated by this nanodevice through pHLIP self-insertion, leaving exposed on the surface PD-1 antibody. This antibody catches circulating T lymphocytes, which express PD-1, and facilitates cytotoxic synapse and communication with cancer cells, provoking immune system-induced-tumor leveling. Moreover, J-pHLIP-PD1 treatment-associated reduction of metastatic burden was also proven in a B16-F10-Luc metastatic model.
Finally, in the seventh and eighth chapter, the general discussion and conclusions derived from the presented experimental studies of this Ph.D. thesis are exposed. In conclusion, the preparation of mesoporous silica nanoparticles and their combination with metal particles and/or organic groups such as molecular gates, enzymatic effectors, environment modifiers, communication mediators, and drugs are presented in this thesis as a potential strategy to overcome tumor treatments limitations. We hope that the results obtained will open up new research opportunities and inspire the development of new advanced strategies with smart materials applied not only in the field of tumor therapy, but also in other biomedical areas to solve patient’s needs.
Time
(Friday) 11:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
24mayAll DayJuli PeretóA CREATIVE PLANET: HOW DID LIFE ON EARTH EMERGE?
Event Details
A CREATIVE PLANET: HOW DID LIFE ON EARTH EMERGE? Juli Peretó I2SYSBIO CSIC-UV Mayo 24 a las 12:30h Salón de Actos CIPF Abstract: The transition from geochemistry to biochemistry took
Event Details
A CREATIVE PLANET: HOW DID LIFE ON EARTH EMERGE?
Juli Peretó I2SYSBIO CSIC-UV
Mayo 24 a las 12:30h
Salón de Actos CIPF
Abstract: The transition from geochemistry to biochemistry took place on Earth some 4 billion years ago. How did the chemistry of the early planet organise itself into systems capable of obtaining matter and energy from the environment and making more copies of themselves? And how did these simple biological systems unfold to generate so much biodiversity? The difficulties of scientific study of the origin of life are enormous, since we do not know most of the details of what the planet was like at that time, and there are hardly any remains of the most primitive cells. The classic proposals of Oparin and Haldane, a century ago, put speculation to rest and opened the way for empirical studies. From the pioneering experiments of Miller and Oró to the most recent approaches of systems chemistry, a long road has been travelled that allows us to recreate today in the laboratory many processes analogous to those that could have occurred during the chemical origin of life on Earth. Admittedly, as in all research of a historical nature, we will never know exactly how chemistry came to life, but this does not prevent us from taking on one of the most colossal and exciting scientific challenges, an unfinished and never-ending scientific programme.
Juli Peretó is professor in the Department of Biochemistry and Molecular Biology (University of Valencia) and full member of the Institut d’Estudis Catalans. He was co-director-founder of the Institute for Integrative Systems Biology (I2SysBio, a joint University of Valencia-CSIC centre) of which he is a member of the Biotechnology and Synthetic Biology group. His research interests include the evolution of metabolism, the concept of the minimal cell, the bioprospecting of inhospitable habitats and the history of ideas about the natural origin and artificial synthesis of life. He tries to teach metabolism with an evolutionary flair to biologists, biochemists and biotechnologists. He was Secretary and Vice-President of the International Society for the Study of the Origin of Life (ISSOL), of which he was elected Fellow in 2014. He is co-founder of the company Darwin Bioprospecting Excellence SL, a spin-off of the University of Valencia installed in its Science Park. Some of his recent books are “Synthetic Biology: from iGEM to the artificial cell” (Springer, 2014), co-authored with M. Porcar, “Science at the table”, a collection of articles on scientific gastronomy by F. Sapiña (Monografies Mètode, 2019), “Illuminating human evolution, 150 years after Darwin”, co-edited with J. Bertranpetit (Springer 2022), and “Un planeta creatiu: com va començar la vida a la Terra i com la fabricarem al laboratori” (Institució Alfons el Magnànim, 2023).
Time
All Day (Friday)(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Event Details
CRISPR-BASED TECHNOLOGIES FOR ENGINEERING MOSQUITO POPULATIONS AND BEYOND Víctor López Del Amo UTHealth Science Center Houston – School of Public Health – Department of Epidemiology (Center for Infectious Diseases) Mayo 30
Event Details
CRISPR-BASED TECHNOLOGIES FOR ENGINEERING MOSQUITO POPULATIONS AND BEYOND
Víctor López Del Amo
UTHealth Science Center Houston – School of Public Health – Department of Epidemiology (Center for Infectious Diseases)
Mayo 30 – 12:00h
Salón Forteza, CIPF
Abstract: Even with extensive efforts to curb its spread, mosquito-borne diseases such as malaria or dengue affect millions of people and cause over 800,000 deaths a year. Though the emergence of CRISPR-based technologies provides promising new tools for controlling these insect pests. One approach, such as CRISPR gene-drive systems, allows biasing Mendelian inheritance rates while propagating genes of interest into a target community for engineering wild populations. A second strategy called precise genetic sterile insect technique (pgSIT) permits the generation of sterile males via a genetic cross for mass release. While gene drives and pgSIT technologies employ the Cas9 nuclease, other nucleases such as the temperature-sensitive Cas12a have not been explored for insect control. Here, we present Cas12a-based next-generation gene drives and pgSIT technologies, bringing new opportunities for vector control while overcoming current issues imposed by the Cas9 nuclease.
Time
(Thursday) 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
june
07junAll DayElisa MartiBuilding Human Spinal Cord Organoids: Biomodels to Study Neural Tube Defects
Event Details
Conference Building Human Spinal Cord Organoids: Biomodels to Study Neural Tube Defects Elisa Marti Instituto Biología Molecular de Barcelona IBMB-CSIC
Event Details
Conference
Building Human Spinal Cord Organoids: Biomodels to Study Neural Tube Defects
Elisa Marti
Instituto Biología Molecular de Barcelona IBMB-CSIC
Time
All Day (Friday)(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
13jun12:3013:30FBR: Carlos GuillénRole of mTORC1 in the progression to type 2 diabetes mellitus
Event Details
Role of mTORC1 in the progression to type 2 diabetes mellitus Speaker: Carlos Guillén Institution: Department of Biochemistry and Molecular Biology. School of Pharmacy Place: Jerónimo Forteza conference room, CIPF Abstract:
Event Details
Role of mTORC1 in the progression to type 2 diabetes mellitus
Speaker: Carlos Guillén
Institution: Department of Biochemistry and Molecular Biology. School of Pharmacy
Place: Jerónimo Forteza conference room, CIPF
Abstract: Type 2 diabetes mellitus (T2DM) is a progressive and multifactorial disease which is characterised by insulin resistance and the appearance of hyperinsulinemia during the first stages of the disease. As a consequence, pancreatic β cells are overwhelmed by its increased
capacity to produce and secrete more insulin, which is known as the pre-diabetic stage. Under this compensatory situation that occurs in β cells during the progression to T2DM, mTORC1 signalling pathway is one of the key regulators of pancreatic cell mass. In addition, there is a
chronic activation of mTORC1 signaling pathway, which induces aging and acts as an endogenous inhibitor of autophagy. Moreover, under this situation, pancreatic β cells start to accumulate amylin protein (IAPP) in aggregates, and this accumulation contributes as well to the ailure of autophagy, damaging different organelles such as plasma membrane, endoplasmic reticulum, mitochondria, and others. Autophagy is involved in the recycling of cellular components for energy generation under nutrient deprivation, and serves as a complementary egradation system to the ubiquitin-proteasome pathway. Autophagy represents a protective mechanism for different cell types, including pancreatic β cells, and potentiates β cell survival across the progression to T2DM. In summary, the chronic overactivation of mTORC1 ignaling pathway in β islets in a prediabetic situation, make these cells more prone to trigger apoptosis upon several cellular stressors and facilitates the progression from prediabetes to type 2 diabetes status.
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-02/2023 and CIAORG/2022/035
Time
(Thursday) 12:30 - 13:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
27jun12:0013:00SEMINAR: Mª del Mar Sánchez / Mohammed M. Anwar
Event Details
12:00 – 12:30 Mª del Mar Sánchez Martín Title Abstract 12:30 – 13:00 Mohammed M. Anwar Title Abstract
Event Details
12:00 – 12:30 Mª del Mar Sánchez Martín
Title
Abstract
12:30 – 13:00 Mohammed M. Anwar
Title
Abstract
Time
(Thursday) 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
july
04jul12:3013:30FBR: Maria Mittelbrunn
Event Details
Title Speaker: Maria Mittelbrunn Institution: Inmunometabolism & Inflammation Lab, Centro de Biología Molecular Severo Ochoa, Madrid, Spain Place: Jerónimo Forteza conference room, CIPF Abstract: PATROCINADO POR:
Event Details
Title
Speaker: Maria Mittelbrunn
Institution: Inmunometabolism & Inflammation Lab, Centro de Biología Molecular Severo Ochoa, Madrid, Spain
Place: Jerónimo Forteza conference room, CIPF
Abstract:
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-02/2023 and CIAORG/2022/035
Time
(Thursday) 12:30 - 13:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
15may19:0020:30Pint of Science 2024CA REVOLTA
Event Details
More Info: https://pintofscience.es/events/valencia
Event Details
More Info: https://pintofscience.es/events/valencia
Time
(Wednesday) 19:00 - 20:30(GMT+02:00)
Location
CA REVOLTA
C/ Santa Teresa, 10
16may12:0013:00SEMINAR: Marina Fuertes Agudo / Daniel Tena González
Event Details
12:00 – 12:30 Marina Fuertes Agudo 3D cell cultures for modeling liver pathologies Abstract 12:30 – 13:00 Daniel Tena González Inhibition of NLRP3 inflammasome in models of retinal degenerations
Event Details
12:00 – 12:30 Marina Fuertes Agudo
3D cell cultures for modeling liver pathologies
Abstract
12:30 – 13:00 Daniel Tena González
Inhibition of NLRP3 inflammasome in models of retinal degenerations
Abstract
Time
(Thursday) 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Event Details
Title: New advanced anti-tumor therapies based on hybrid mesoporous nanodevices Autor: Elena Lucena Sánchez Abstract: The present PhD thesis entitled “New advanced anti-tumor therapies based on hybrid mesoporous nanodevices” focuses
Event Details
Title: New advanced anti-tumor therapies based on hybrid mesoporous nanodevices
Autor: Elena Lucena Sánchez
Abstract: The present PhD thesis entitled “New advanced anti-tumor therapies based on hybrid mesoporous nanodevices” focuses on the design, synthesis, characterization, and evaluation of new hybrid organic-inorganic nanodevices. We have developed mesoporous silica nanoparticles (MSNs) and Janus platinum-MSN and gold-MSN nanoparticles for tumor treatment.
The first chapter is a general introduction that includes an overview of the context related to the research developed in this thesis. In particular, the concept of nanotechnology and nanomedicine are presented, as well as basic information about mesoporous silica nanoparticles, janus nanoparticles, and their interactions with biological systems. Finally, cancer disease characteristics, actual treatments, and the application of nanomaterials as therapy are described.
Next, in the second chapter, the general objectives of this Ph.D. thesis and the specific objectives addressed in the following experimental chapters are presented.
The third and fourth chapters describe two nanotechnology-based therapeutic strategies based on the development of nanomotors to improve cancer therapy. Specifically, the first experimental chapter presents a self-moving nanodevice for controlled drug release in response to intracellular glutathione (GSH). It is based on Janus gold-mesoporous silica nanoparticles functionalized with the enzyme catalase in the gold face, loaded with doxorubicin and capped with disulfide-linked oligo(ethylene glycol) (S-S-PEG) chains on the silica face. Once synthesized and characterized, the nanosystem motion capability through hydrogen peroxide (fuel) conversion into oxygen by catalase was confirmed. The proper gating mechanism of the nanodevice was tested in the presence of GSH, thus corroborating that cargo release only occurs in the presence of the tripeptide. The cellular uptake and doxorubicin release capacity have been demonstrated in the human cervix cell line Hela, being increased in the presence of fuel.
Encouraged by the above results, chapter four describes a similar nanomotor design for antitumor therapy. In this case, the nanoparticle developed is composed of a Janus platinum-mesoporous silica nanoparticle, loaded with doxorubicin, and capped with S-S-PEG. As well as in the previous work, the catalytic decomposition of low concentrations of hydrogen peroxide, in this case by platinum, induced self-propulsion of the nanoparticles. The stimuli-responsive
cargo release kinetic profile was obtained and its application was confirmed in a monolayer THP-1 cell culture and in a microchip device mimicking capillary vessels.
Chapters five and six focus on a new therapeutic strategy, empowering the immune system action on tumors to reach tumor cell death. In the first of these experimental chapters, JQ-1 and transforming growth factor-beta (TGF-β) siRNA-loaded nanoparticles were used as efficient tumor immunotherapy. This nanodevice is based on MSNs loaded with JQ-1 drug, functionalized with polyethyleneimine (PEI) and a siRNA targeting TGF-β was binding through electrostatic interaction. The endosomal escape and efficient cytosolic delivery of siRNA by PEI was accomplished by using these nanoparticles, along with the programmed death-ligand 1 (PD-L1) downregulation and TGF-β silencing. Lastly, its application was confirmed by triggering a specific immunogenic removal of tumor cells in melanoma A375 cells pre-treated with nanoparticles.
In chapter six, the development of a new communication-based immunotherapeutic approach is reported. In this case, we employ Janus gold-MSN functionalized with a peptide called pHLIP onto silica face and anti-PD-1 antibody bound to gold face (J-pHLIP-PD1). Tumor cell membrane is decorated by this nanodevice through pHLIP self-insertion, leaving exposed on the surface PD-1 antibody. This antibody catches circulating T lymphocytes, which express PD-1, and facilitates cytotoxic synapse and communication with cancer cells, provoking immune system-induced-tumor leveling. Moreover, J-pHLIP-PD1 treatment-associated reduction of metastatic burden was also proven in a B16-F10-Luc metastatic model.
Finally, in the seventh and eighth chapter, the general discussion and conclusions derived from the presented experimental studies of this Ph.D. thesis are exposed. In conclusion, the preparation of mesoporous silica nanoparticles and their combination with metal particles and/or organic groups such as molecular gates, enzymatic effectors, environment modifiers, communication mediators, and drugs are presented in this thesis as a potential strategy to overcome tumor treatments limitations. We hope that the results obtained will open up new research opportunities and inspire the development of new advanced strategies with smart materials applied not only in the field of tumor therapy, but also in other biomedical areas to solve patient’s needs.
Time
(Friday) 11:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
24mayAll DayJuli PeretóA CREATIVE PLANET: HOW DID LIFE ON EARTH EMERGE?
Event Details
A CREATIVE PLANET: HOW DID LIFE ON EARTH EMERGE? Juli Peretó I2SYSBIO CSIC-UV Mayo 24 a las 12:30h Salón de Actos CIPF Abstract: The transition from geochemistry to biochemistry took
Event Details
A CREATIVE PLANET: HOW DID LIFE ON EARTH EMERGE?
Juli Peretó I2SYSBIO CSIC-UV
Mayo 24 a las 12:30h
Salón de Actos CIPF
Abstract: The transition from geochemistry to biochemistry took place on Earth some 4 billion years ago. How did the chemistry of the early planet organise itself into systems capable of obtaining matter and energy from the environment and making more copies of themselves? And how did these simple biological systems unfold to generate so much biodiversity? The difficulties of scientific study of the origin of life are enormous, since we do not know most of the details of what the planet was like at that time, and there are hardly any remains of the most primitive cells. The classic proposals of Oparin and Haldane, a century ago, put speculation to rest and opened the way for empirical studies. From the pioneering experiments of Miller and Oró to the most recent approaches of systems chemistry, a long road has been travelled that allows us to recreate today in the laboratory many processes analogous to those that could have occurred during the chemical origin of life on Earth. Admittedly, as in all research of a historical nature, we will never know exactly how chemistry came to life, but this does not prevent us from taking on one of the most colossal and exciting scientific challenges, an unfinished and never-ending scientific programme.
Juli Peretó is professor in the Department of Biochemistry and Molecular Biology (University of Valencia) and full member of the Institut d’Estudis Catalans. He was co-director-founder of the Institute for Integrative Systems Biology (I2SysBio, a joint University of Valencia-CSIC centre) of which he is a member of the Biotechnology and Synthetic Biology group. His research interests include the evolution of metabolism, the concept of the minimal cell, the bioprospecting of inhospitable habitats and the history of ideas about the natural origin and artificial synthesis of life. He tries to teach metabolism with an evolutionary flair to biologists, biochemists and biotechnologists. He was Secretary and Vice-President of the International Society for the Study of the Origin of Life (ISSOL), of which he was elected Fellow in 2014. He is co-founder of the company Darwin Bioprospecting Excellence SL, a spin-off of the University of Valencia installed in its Science Park. Some of his recent books are “Synthetic Biology: from iGEM to the artificial cell” (Springer, 2014), co-authored with M. Porcar, “Science at the table”, a collection of articles on scientific gastronomy by F. Sapiña (Monografies Mètode, 2019), “Illuminating human evolution, 150 years after Darwin”, co-edited with J. Bertranpetit (Springer 2022), and “Un planeta creatiu: com va començar la vida a la Terra i com la fabricarem al laboratori” (Institució Alfons el Magnànim, 2023).
Time
All Day (Friday)(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
Event Details
CRISPR-BASED TECHNOLOGIES FOR ENGINEERING MOSQUITO POPULATIONS AND BEYOND Víctor López Del Amo UTHealth Science Center Houston – School of Public Health – Department of Epidemiology (Center for Infectious Diseases) Mayo 30
Event Details
CRISPR-BASED TECHNOLOGIES FOR ENGINEERING MOSQUITO POPULATIONS AND BEYOND
Víctor López Del Amo
UTHealth Science Center Houston – School of Public Health – Department of Epidemiology (Center for Infectious Diseases)
Mayo 30 – 12:00h
Salón Forteza, CIPF
Abstract: Even with extensive efforts to curb its spread, mosquito-borne diseases such as malaria or dengue affect millions of people and cause over 800,000 deaths a year. Though the emergence of CRISPR-based technologies provides promising new tools for controlling these insect pests. One approach, such as CRISPR gene-drive systems, allows biasing Mendelian inheritance rates while propagating genes of interest into a target community for engineering wild populations. A second strategy called precise genetic sterile insect technique (pgSIT) permits the generation of sterile males via a genetic cross for mass release. While gene drives and pgSIT technologies employ the Cas9 nuclease, other nucleases such as the temperature-sensitive Cas12a have not been explored for insect control. Here, we present Cas12a-based next-generation gene drives and pgSIT technologies, bringing new opportunities for vector control while overcoming current issues imposed by the Cas9 nuclease.
Time
(Thursday) 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
07junAll DayElisa MartiBuilding Human Spinal Cord Organoids: Biomodels to Study Neural Tube Defects
Event Details
Conference Building Human Spinal Cord Organoids: Biomodels to Study Neural Tube Defects Elisa Marti Instituto Biología Molecular de Barcelona IBMB-CSIC
Event Details
Conference
Building Human Spinal Cord Organoids: Biomodels to Study Neural Tube Defects
Elisa Marti
Instituto Biología Molecular de Barcelona IBMB-CSIC
Time
All Day (Friday)(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
13jun12:3013:30FBR: Carlos GuillénRole of mTORC1 in the progression to type 2 diabetes mellitus
Event Details
Role of mTORC1 in the progression to type 2 diabetes mellitus Speaker: Carlos Guillén Institution: Department of Biochemistry and Molecular Biology. School of Pharmacy Place: Jerónimo Forteza conference room, CIPF Abstract:
Event Details
Role of mTORC1 in the progression to type 2 diabetes mellitus
Speaker: Carlos Guillén
Institution: Department of Biochemistry and Molecular Biology. School of Pharmacy
Place: Jerónimo Forteza conference room, CIPF
Abstract: Type 2 diabetes mellitus (T2DM) is a progressive and multifactorial disease which is characterised by insulin resistance and the appearance of hyperinsulinemia during the first stages of the disease. As a consequence, pancreatic β cells are overwhelmed by its increased
capacity to produce and secrete more insulin, which is known as the pre-diabetic stage. Under this compensatory situation that occurs in β cells during the progression to T2DM, mTORC1 signalling pathway is one of the key regulators of pancreatic cell mass. In addition, there is a
chronic activation of mTORC1 signaling pathway, which induces aging and acts as an endogenous inhibitor of autophagy. Moreover, under this situation, pancreatic β cells start to accumulate amylin protein (IAPP) in aggregates, and this accumulation contributes as well to the ailure of autophagy, damaging different organelles such as plasma membrane, endoplasmic reticulum, mitochondria, and others. Autophagy is involved in the recycling of cellular components for energy generation under nutrient deprivation, and serves as a complementary egradation system to the ubiquitin-proteasome pathway. Autophagy represents a protective mechanism for different cell types, including pancreatic β cells, and potentiates β cell survival across the progression to T2DM. In summary, the chronic overactivation of mTORC1 ignaling pathway in β islets in a prediabetic situation, make these cells more prone to trigger apoptosis upon several cellular stressors and facilitates the progression from prediabetes to type 2 diabetes status.
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-02/2023 and CIAORG/2022/035
Time
(Thursday) 12:30 - 13:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
27jun12:0013:00SEMINAR: Mª del Mar Sánchez / Mohammed M. Anwar
Event Details
12:00 – 12:30 Mª del Mar Sánchez Martín Title Abstract 12:30 – 13:00 Mohammed M. Anwar Title Abstract
Event Details
12:00 – 12:30 Mª del Mar Sánchez Martín
Title
Abstract
12:30 – 13:00 Mohammed M. Anwar
Title
Abstract
Time
(Thursday) 12:00 - 13:00(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
04jul12:3013:30FBR: Maria Mittelbrunn
Event Details
Title Speaker: Maria Mittelbrunn Institution: Inmunometabolism & Inflammation Lab, Centro de Biología Molecular Severo Ochoa, Madrid, Spain Place: Jerónimo Forteza conference room, CIPF Abstract: PATROCINADO POR:
Event Details
Title
Speaker: Maria Mittelbrunn
Institution: Inmunometabolism & Inflammation Lab, Centro de Biología Molecular Severo Ochoa, Madrid, Spain
Place: Jerónimo Forteza conference room, CIPF
Abstract:
PATROCINADO POR:
With support from the Generalitat Valenciana, AMPER-02/2023 and CIAORG/2022/035
Time
(Thursday) 12:30 - 13:30(GMT+02:00)
Location
Centro de Investigación Príncipe Felipe
Eduardo Primo Yúfera, 3 Valencia Spain
lectures
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Eva Hernando Monge
Mechanisms of neural mimicry during melanoma metastasis Speaker: Eva Hernando-Monge...
DISCOVER
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NEURODEGENERATIVE DISORDERS
CANCER AND INFLAMMATION
AND REGERENATIVE MEDICINE
MIGRATION AND CANCER INVASION
BIOENGINEERING
HOST-MICROBIOME INTERACTIONS